1-Panel Urine Test:
OPI

FDA Cleared

Item: DOP-114

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Panel Target Compound Cutoff Level
OPI Morphine 2,000 ng/mL
OPI Panel: Specifications

Specificity - OPI Drug Test Panel

The following compounds are detected positive in urine by the OPI One Step Opiates Drug Test at 5 minutes. Cutoff represents the concentration of each compound required to yield a positive reading. A lower cutoff indicates a greater ability to detect the compound.

Compound Description / Synonyms / Brand Names / Common Names Cutoff
(ng/mL)
Morphine Painkillers, Pain Pills, Morphin, Morfina / Astramorph, Duramorph, Embeda, Infumorph, Kadian, Mitigo, Morphabond, MS Contin 2,000
Codeine Methylmorphine, Codein, Codeina / Fioricet with Codeine, Fiorinal with Codeine, Prometh VC with Codeine, Triacin, Tuxarin, Tuzistra, Tylenol with Codeine 2,000
Ethylmorphine Codethyline, Ethylmorphin 5,000
Hydrocodone Painkillers, Pain Pills, Dihydrocodeinone, Hydrocodon, Hidrocodona, Idrocodone / Anexsia, Hysingla, Norco, Obredon, Reprexain, Rezira, TussiCaps, Tussigon, Vituz, Zohydro, Zutripro 12,500
Hydromorphone Painkillers, Pain Pills, Dihydromorphinone, Hydromorphon, Hydromorfona, Hidromorfona, Idromorfone / Dilaudid, Exalgo / Dillies 5,000
Levorphanol Levorphan, Levorfanol 75,000
6-Monoacetyl-morphine Heroin metabolite / 6-Acetylmorphine, 6-AM, 6-MAM 5,000
Morphine 3-B-D-glucuronide Morphine and heroin metabolite / M3G, Morphine glucuronide, Morphine 3-beta-D-glucuronide, Morphine 3-β-D-glucuronide 2,000
Norcodeine Codeine metabolite / Norcodeina 12,500
Normorphone Morphine and heroin metabolite / Normorphine, Normorfina 50,000
Oxycodone Painkillers, Pain Pills, Oxycodon, Oxicodona, Ossicodone / Oxaydo, Oxycet, OxyContin, Percocet, Percodan, Roxicet, Roxicodone, Xtampza / Blues, Oxy, Percs, Roxies 25,000
Oxymorphone Painkillers, Pain Pills, Oxymorphine, Oxymorphon, Oximorfona / Opana 25,000
Procaine Procain, Procaina 150,000
Thebaine Paramorphine 100,000

Opiates - Definition and Description

The opiates are a group of narcotic analgesic drugs derived from the opium poppy, belonging to the broader opioid drug family. Opiates take on many forms and can have both licit and illicit origins. Licit forms are available in the US only by prescription and for use by licensed medical facilities, dispensed primarily as analgesics and as antitussives. Licit opiates include, most notably: morphine, codeine, hydrocodone, hydromorphone, oxycodone, oxymorphone, buprenorphine, and opium tinctures. Illicit opiates include heroin, raw opium, and any commercially produced opiates that are diverted prescriptions or the subjects of other forms of diversion.

Opiates are notorious for being highly addictive and are prone to producing strong physical dependence. In addition, opiates produce strong euphoric effects. As a result, they are heavily targeted by recreational users and by the opiate addicted, who require a continuous supply in order to avoid harsh withdrawal symptoms.

For more information, see: Opiates Facts and Information.

Summary - OPI Opiates Urine Test Panel

Morphine is the target compound for the OPI One Step Opiate Drug Test, detected at a cutoff level of 2,000 ng/mL. Morphine is a prescription painkiller, found in the form of oral tablets, oral capsules, oral solutions, and injectable forms. Morphine is available by prescription only and is indicated for treating pain — under many generic labels and the brands: Astramorph, Duramorph, Embeda, Infumorph, Kadian, Mitigo, Morphabond, and MS Contin. Morphine can also be found in opium tinctures, known as laudanum and paregoric. These tinctures are solutions of anhydrous morphine in alcohol and water, prescribed for treating diarrhea. Following a morphine dose, approximately 45–55% is recovered in the urine as morphine 3-B-D-glucuronide (M3G), 10–15% as morphine 6-B-D-glucuronide (M6G), and less than 10% as free morphine. [1]

Morphine 3-B-D-glucuronide (M3G) cross-reacts with this test at 2,000 ng/mL. M3G is morphine's (and heroin's) major urinary metabolite, with approximately 45–55% of a morphine dose excreted in the urine as M3G. [1]

Urinary metabolites of heroin are very similar to morphine's. Following heroin use, approximately 57% is recovered in the urine as conjugated morphine (primarily morphine 3-B-D-glucuronide (M3G) and morphine 6-B-D-glucuronide (M6G)), 5% as free morphine, and less than 1% as 6-monoacetylmorphine (6-MAM). [2] Heroin is found in the form of a white to brown powder and is typically snorted or liquefied and injected. Heroin is illegal in the United States, with no accepted medical purpose.

Codeine cross-reacts with this test at 2,000 ng/mL. Codeine is available by prescription only, primarily in combination with other drugs, in the form of oral tablets, oral capsules, and oral solutions. Some combinations are indicated for treating pain, under many generic labels and the brands: Fioricet with Codeine, Fiorinal with Codeine, and Tylenol with Codeine. Other combinations are indicated for treating coughs and respiratory symptoms, under many generic labels and the brands: Prometh VC with Codeine, Triacin, Tuxarin, and Tuzistra. Codeine can also be found in the form of purple drank, also known as sizzurp or lean — a codeine-based concoction abused in many urban and suburban regions of the United States. Approximately 5–17% of a codeine dose is excreted in the urine as free codeine. [3]

Oxycodone cross-reacts with this test at 25,000 ng/mL. However, this cutoff level is prohibitively high for the reliable detection of oxycodone use. Instead, an oxycodone urine test device should be employed, such as the 1-panel OXY One Step Oxycodone Drug Test (or a multi-panel drug test that contains an OXY panel), which targets oxycodone at 100 ng/mL.

Related Pages

References

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  1. Glare PA, Walsh TD. (1991, Jan). "Clinical Pharmacokinetics of Morphine". Therapeutic Drug Monitoring, 13(1): 1–23. PMID:2057987
  2. Cone EJ, Welch P, Mitchell JM, Paul BD. (1991, Jan/Feb). "Forensic Drug Testing for Opiates: I. Detection of 6-Acetylmorphine in Urine as an Indicator of Recent Heroin Exposure; Drug and Assay Considerations and Detection Times". Journal of Analytical Toxicology, 15(1): 1–7. PMID:2046334
  3. Baselt RC, Cravey RH. (1989). "Disposition of Toxic Drugs and Chemicals in Man" (3rd ed, pp 214–216). USA: Year Book Medical Publishers, Inc.

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