1-Panel Urine Test:
COC

FDA Cleared

Item: DCO-114

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Panel Target Compound Cutoff Level
COC Benzoylecgonine 300 ng/mL
COC Panel: Specifications

Specificity - COC Drug Test Panel

The following compounds are detected positive in urine by the COC One Step Cocaine Drug Test at 5 minutes. Cutoff represents the concentration of each compound required to yield a positive reading. A lower cutoff indicates a greater ability to detect the compound.

Compound Description / Synonyms / Brand Names / Common Names Cutoff
(ng/mL)
Benzoylecgonine Cocaine metabolite 300
Cocaine Benzoyl-methylecgonine, Methyl-benzoylecgonine, Cocain, Cocaina, Cocainum / Goprelto / Coke 780
Cocaethylene Cocaine metabolite / Ethylcocaine, Benzoyl-ethylecgonine, Ethyl-benzoylecgonine 12,500
Ecgonine Cocaine metabolite 32,000

Cocaine - Definition and Description

Cocaine is a potent CNS stimulant and anorectic, with a high potential for addiction and abuse. Street cocaine is found in two basic forms: cocaine salt (powder cocaine) and cocaine base (freebase, crack). Powder cocaine is purchased in the form of small, white to off-white, soft rocks, which are converted to powder by cutting with a razor blade or by crushing. The powder is then snorted, though it might also be liquefied and injected. Freebase cocaine is powder cocaine that has been processed with ammonia or baking soda into a purer and harder, rock form, which is smoked. More commonly, baking soda is used and the end product is known as crack cocaine.

In 2017, the US FDA approved a new drug containing a 4% cocaine hydrochloride solution, marketed under the brand name Goprelto. The drug was approved under a very limited scope — indicated for the induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities in adults.

Cocaine is one of the most prevalent illicit drugs in the United States, ranked third in 2013, behind marijuana and the illicit use of prescription drugs[1] Cocaine's potent stimulant properties produce heightened levels of energy and euphoria, in addition to sleep deprivation. Cocaine produces powerful drug cravings, causing many users to go to great lengths in order to procure more drug when supply is depleted. Cocaine is also extremely expensive, leading to many domestic, social, legal, and financial problems for the cocaine addicted and users who continuously seek to replenish supply.

For more information, see: Cocaine Facts and Information.

Summary - COC Cocaine Urine Test Panel

Benzoylecgonine is the target compound for the COC One Step Cocaine Drug Test, detected at a cutoff level of 300 ng/mL. Benzoylecgonine is a major urinary metabolite of cocaine and is the standard target compound used by cocaine urine screen tests. Approximately 35–54% of a cocaine dose is recovered in the urine as benzoylecgonine, with approximately 32–49% recovered as the metabolite ecgonine methyl ester. [2]

Cocaine cross-reacts with this test at 780 ng/mL. Approximately 1–9% of a cocaine dose is recovered in the urine as unchanged cocaine. [2]

Freebase (Crack cocaine), when smoked, yields the same major urinary metabolites found when powder cocaine is used orally, nasally, or intravenously: primarily benzoylecgonine, ecgonine methyl ester, and unchanged cocaine, with the highest concentrations consisting of benzoylecgonine. [3]

Related Pages

References

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  1. (2015, Jun). "Nationwide Trends". National Institute on Drug Abuse, DrugFacts. Retrieved Dec 4, 2018, from: https://www.drugabuse.gov/publications/drugfacts/nationwide-trends
  2. Baselt RC, Cravey RH. (1989). "Disposition of Toxic Drugs and Chemicals in Man" (3rd ed, pp 208–212). USA: Year Book Medical Publishers, Inc.
  3. Huestis MA, Darwin WD, Shimomura E, Lalani SA, Trinidad DV, Jenkins AJ, Cone EJ, Jacobs AJ, Smith ML, Paul BD. (2007, Oct). "Cocaine and Metabolites Urinary Excretion after Controlled Smoked Administration". Journal of Analytical Toxicology, 31(8): 462–468. PMCID:PMC3128807, [PDF file]

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