1-Panel Urine Test:
COC

Item: DCO-114

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Panel Target Compound Cutoff Level
COC Benzoylecgoninee 300 ng/mL
COC Panel: Specifications

Summary - COC Drug Test Panel

  • Cocaine, commonly known as coke, is a potent CNS stimulant drug with a high potential for addiction and misuse. In years past, cocaine was used medically as a local anesthetic. Currently, cocaine is illegal in the United States, where it is found primarily in two forms: powder cocaine and crack cocaine. Powder cocaine is typically purchased in the form of small, white to off-white, soft rocks, which are converted to powder by cutting with a razor blade or by crushing. The powder is then snorted using a small straw or rolled currency. The powder might also be liquefied and injected. Crack cocaine is powder cocaine that has been processed, typically with baking soda, into a harder rock form, which is smoked. Freebase is another name for crack cocaine. [1]

  • Cocaine is one of the most prevalent illicit drugs in the United States, ranked third in 2013, behind marijuana and the illicit use of prescription drugs. [2] Cocaine's potent stimulant properties produce heightened levels of energy and euphoria, in addition to sleep deprivation. Cocaine produces powerful drug cravings, causing many users to go to great lengths in order to procure more drug when supply is depleted. To lessen cocaine's effects or to expedite sleep following a cocaine episode, many users turn to sedatives such as benzodiazepines (Xanax) or barbiturates. When potent CNS drugs are combined in such fashions, or when combined with alcohol, results can be unpredictable and at worst fatal. [3] Cocaine is extremely addictive and expensive, leading to many domestic, social, legal, and financial problems for the cocaine addicted and users who continuously seek to replenish supply. [4]

  • Benzoylecgonine is the target compound for the COC One Step Cocaine Drug Test, detected at a cutoff level of 300 ng/mL. Benzoylecgonine is a major urinary metabolite of cocaine and is the standard target compound used by most cocaine urine screen tests. Approximately 35–54% of a cocaine dose is excreted in the urine as benzoylecgonine, with approximately 32–49% excreted as the metabolite ecgonine methyl ester. [5]

  • Cocaine cross-reacts with this test at 780 ng/mL. Approximately 1–9% of a cocaine dose is excreted in the urine as unchanged cocaine. [5]

  • Crack cocaine, when smoked, yields the same major urinary metabolites found when powder cocaine is used orally, nasally, or intravenously: primarily benzoylecgonine, ecgonine methyl ester, and unchanged cocaine, with the highest concentrations consisting of benzoylecgonine. [6]

Specificity - COC Drug Test Panel

The following compounds are detected positive in urine by the COC One Step Cocaine Drug Test at 5 minutes. Cutoff represents the concentration of each compound required to yield a positive reading, expressed in nanograms of compound per milliliter of urine (ng/mL). A lower cutoff indicates a greater ability to detect the compound.

Compound Description / Synonyms / Common Names Cutoff
(ng/mL)
Benzoylecgonine Cocaine metabolite 300
Cocaine Benzoylmethylecgonine, Methylbenzoylecgonine, Cocain, Cocaina, Cocainum / Coke 780
Cocaethylene Cocaine metabolite / Ethylcocaine, Benzoylethylecgonine, Ethylbenzoylecgonine 12,500
Ecgonine Cocaine metabolite 32,000