1-Panel Urine Test:
BUP

FDA Cleared

Item: DBU-114

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1 to 9 $1.95
10 to 24 $1.60
25 to 99 $1.25
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Panel Target Compound Cutoff Level
BUP Buprenorphine 10 ng/mL
BUP Panel: Specifications

Specificity - BUP Drug Test Panel

The following compounds are detected positive in urine by the BUP One Step Buprenorphine Drug Test at 5 minutes. Cutoff represents the concentration of each compound required to yield a positive reading. A lower cutoff indicates a greater ability to detect the compound.

Compound Description / Synonyms / Brand Names / Common Names Cutoff
(ng/mL)
Buprenorphine Buprenorphin, Buprenorfina / Belbuca, Bunavail, Buprenex, Butrans, Cassipa, Probuphine, Sublocade, Suboxone, Zubsolv / Subs 10
Buprenorphine 3-B-D-glucuronide Buprenorphine metabolite / B3G, Buprenorphine glucuronide, Buprenorphine 3-beta-D-glucuronide, Buprenorphine 3-β-D-glucuronide 15
Norbuprenorphine Buprenorphine metabolite 20
Norbuprenorphine 3-B-D-glucuronide Buprenorphine metabolite / NB3G, Norbuprenorphine glucuronide, Norbuprenorphine 3-beta-D-glucuronide, Norbuprenorphine 3-β-D-glucuronide 200

Buprenorphine - Definition and Description

Buprenorphine is a semi-synthetic opiate, belonging to the broader opioid drug family. Buprenorphine is frequently referred to as Suboxone, the most prominent commercial brand. Buprenorphine is available in the United States only by prescription and for use by licensed medical facilities. Street buprenorphine is commercially produced buprenorphine that is either a diverted prescription or the subject of another form of diversion. Buprenorphine is classified as a narcotic analgesic, available in monoproduct form and in combination with naloxone in order to discourage misuse by injection. Prescription buprenorphine is found in a wide variety of forms: as oral tablets, sublingual or buccal films, transdermal patches, subdermal implants, and injectable forms.

Buprenorphine acts in the brain as both an opioid partial agonist and an opioid antagonist, effective at curbing cravings and withdrawal symptoms in users who have developed physical dependence on opioids. While it can be prescribed for treating pain, buprenorphine is better known for treating opioid use disorder (OUD), where it is used as a replacement drug during Medication-assisted therapy (MAT). Similar to the opioids it is intended to replace, buprenorphine is prone to abuse and is highly addictive, capable of producing harsh withdrawal symptoms when abstinence is attempted by users with physical dependence on buprenorphine or other opioids. [1]

For more information, see: Buprenorphine Facts and Information.

Summary - BUP Buprenorphine Urine Test Panel

Buprenorphine is the target compound for the BUP One Step Buprenorphine Drug Test, detected at a cutoff level of 10 ng/mL. Buprenorphine is prescribed for treating pain and for treating opioid dependence, available in monoproduct form and in combination with naloxone to discourage misuse by injection. Buprenorphine is found in the form of oral tablets, sublingual or buccal films, transdermal patches, subdermal implants, and injectable forms — dispensed under generic labels and the brands Belbuca, Bunavail, Buprenex, Butrans, Cassipa, Probuphine, Sublocade, Suboxone, and Zubsolv. Following a buprenorphine dose, approximately 11% is recovered in the urine as norbuprenorphine 3-B-D-glucuronide (NB3G), 9.4% as buprenorphine 3-B-D-glucuronide (B3G), 2.7% as free norbuprenorphine, and 1% as free buprenorphine. [2]

Buprenorphine 3-B-D-glucuronide (B3G) cross-reacts with this test at 15 ng/mL and Norbuprenorphine 3-B-D-glucuronide (NB3G) cross-reacts with this test at 200 ng/mL. B3G and NB3G are buprenorphine's major urinary metabolites, with approximately 9.4% and 11% of a buprenorphine dose recovered in the urine as B3G and NB3G, respectively. [2]

Norbuprenorphine cross-reacts with this test at 20 ng/mL. Norbuprenorphine is a urinary metabolite of buprenorphine, with approximately 2.7% of a buprenorphine dose recovered in the urine as norbuprenorphine. [2]

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