Oxycodone Fact Card
What is oxycodone?
Derived from thebaine,  oxycodone is a potent semi-synthetic opiate painkiller, belonging to the broader opioid drug family. Classified as a narcotic analgesic, oxycodone is available in the United States only by prescription and for use by licensed medical facilities. Oxycodone is prescribed for treating varying levels of pain — found in the form of oral tablets, oral capsules, and oral solutions. Prescription oxycodone is available in both monoproduct form and in combination with other drugs (coformulations), including acetaminophen, aspirin, and ibuprofen. Street oxycodone is licitly manufactured oxycodone that is either a diverted prescription or the subject of another form of diversion. In 2016, the United States accounted for 69.2% of oxycodone's global manufacture and 72.9% of its global consumption. 
Oxycodone Abuse and Addiction
Oxycodone produces strong euphoric effects similar to heroin, making it the most sought-after drug among recreational users and abusers of opioids. In attempt to maximize its effects or speed of onset, many users crush the tablets into a powder form and consume the product by snorting, smoking, or injecting after liquefying.  In addition, many are likely to combine the drug with a benzodiazepine such as Xanax in order to enhance the effects of the oxycodone. When potent CNS drugs are combined in such fashions, or when combined with alcohol, results can be unpredictable and at worst fatal.  In the United States in 2011, over 151,000 emergency room incidents were estimated to be related to non-medical use of oxycodone.
Oxycodone is powerfully addictive and prone to producing strong physical dependence. Many bouts with oxycodone addiction begin with an accident or injury, followed by a prescription for the painkiller. Oxycodone users typically develop a drug tolerance quickly, often requiring higher doses to achieve the desired results. Once physical dependence develops, the patient is in a precarious position. When prescriptions are terminated, many patients have difficulty coping with the harsh withdrawal symptoms and continue using painkillers obtained through diverted sources. Due to the high cost of illicit oxycodone on the street, many turn to cheaper opioid alternatives, such as heroin or diverted buprenorphine (Suboxone). For the opioid addicted attempting abstinence, withdrawal symptoms can be debilitating and long lasting, often requiring professional assistance. 
Urine Testing for Oxycodone
Oxycodone urine tests target oxycodone, with possible cross-reactivity for a list of different opiates, including hydrocodone, hydromorphone, and oxymorphone. Oxycodone is prominent as unchanged parent drug in the urine of those ingesting oxycodone.  Hydrocodone is prominent as unchanged parent drug in the urine of those ingesting hydrocodone.  Hydromorphone is prominent as unchanged parent drug in the urine of those ingesting hydromorphone.  Oxymorphone is present in small concentrations in the urine of those ingesting oxymorphone or oxycodone. 
In a study published in the Journal of Analytical Toxicology, volunteers received single doses of oral oxycodone tablets and subsequently submitted to urinalysis screening. A mean of approximately 8% of doses was recovered in the urine as unchanged free oxycodone, 19.2% as free noroxycodone, and 3.1% as free noroxymorphone.